Magic mushrooms have recently sparked interest due to their potential in assisting with various mental health issues, particularly depression. An increasingly popular approach involves a regular intake of approximately 25 mg of the active substance, available at a mushroom dispensary. This dosage seems to provide promising relief and could be a supplementary treatment to conventional depression therapies.
A team of researchers indicates that psilocybin, the active component in magic mushrooms, has demonstrated positive results in treating depression.
Key Insights:
- Psilocybin may improve symptoms of depression in as few as eight days.
- The side effects of psilocybin are generally mild to moderate and are often well-tolerated.
- A dose of 25mg of psilocybin can result in altered perception, mood changes, increased creativity, and a feeling of unity.
One Dose Could Be Enough
A recent study employed a rigorous approach, using a randomized, multi-blind design to compare a single dose of psilocybin with an active placebo (niacin). The study evaluated the onset, duration of effects, and safety of psilocybin over a six-week period.
The Study Participants
The study included individuals aged from 21 to 65 who met the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) criteria for Major Depressive Disorder (MDD) and were undergoing a depressive episode lasting at least 60 days at the time of the study.
The Procedure
Participants were administered a single 25-mg oral dose of psilocybin or a 100-mg dose of niacin. Niacin served as an active placebo, causing an immediate physiological response (flushing) to maintain the integrity of the blind design.
The psilocybin and niacin placebo were given following a standard “set and setting” protocol. The preparatory sessions, conducted with two facilitators, lasted between 6 and
The dosing session generally lasted between 7 to 10 hours, conducted in a calm and relaxed environment. Participants were advised to ponder on their experiences, four hours after they received the dosage.
Research Findings
Significant reduction in depression symptoms were observed as early as eight days following the psilocybin treatment. This promising effect was consistent throughout the six-week follow-up period. It showed enhanced response and remission rates according to the Montgomery-Asberg Depression Rating Scale (MADRS), when compared with other psilocybin studies on Treatment-Resistant Depression.
In comparison to niacin, psilocybin yielded better psychosocial performance. The use of psilocybin displayed potential in multiple aspects such as reducing overall severity of the disease, decreasing anxiety, lowering self-reported depressive symptoms, and improving quality of life.
The majority of participants tolerated the compound well, experiencing only minor to moderate side effects, predominantly with the first dose. However, compared to niacin, psilocybin treatment resulted in more frequent and intense side effects, which is consistent with our current understanding of its effects.
The researchers underscored that psychedelics like psilocybin could trigger side effects that may not always be identified by standard rating scales, or it could reveal previously undiagnosed psychiatric conditions, even while effectively treating specific disorders.
Implications of a 25-mg Dose
Usual psychedelic doses range between 15 to 25 milligrams of psilocybin (equivalent to 1.5 to 2.5 grams of dried mushrooms). This is the accepted dosage for individuals seeking the complete psychedelic effects of magic mushrooms.
This dosage may result in altered perception, mood variation, enhanced creativity, and a profound connection with the environment. Mild visual effects might be experienced, but severe hallucinations are rare. It’s akin to entering a vivid dream-like world where reality intermixes with a captivating amalgamation of visual and auditory sensations.
These ecstatic feelings often express themselves through dance, gentle movements, or by simply yielding to the psychedelic rhythm. The experience typically lasts between 4 to 8 hours. At this stage, visual distortions may become more pronounced. Patterns appear to move and change, and the surroundings seem to pulsate with energy.
While this dosage can be managed, it necessitates a controlled environment and a positive mindset. It offers a journey of amazement and discovery, urging you to delve into the depths of consciousness. with careful excitement.
- Significant enhancements in color perception.
- Visual distortions such as fluctuating or “breathing” objects.
- Experiencing synesthesia, like “seeing sounds” or “hearing colours”.
- Gaining a deeper understanding of music.
- Experiencing fits of laughter.
- Changes in the sense of touch.
- Engaging in introspection.
- Experiencing intense joy.
- Experiencing alterations in the perception of time.
- Experiencing an elevation in heart rate and blood pressure.
Products on Offer at Magic Mushroom Stores
Magic mushroom stores offer a variety of products infused with psilocybin. These stores offer a wide range of options including dried mushrooms, edibles, capsules, drinks, and more. Dried mushrooms are particularly popular.
Health Canada recognizes over 200 types of magic mushrooms, with Psilocybe cubensis being commonly sold. This strain is available in several varieties, providing customers with a broad selection similar to what is offered at cannabis dispensaries.
Other Shroom Products:
| Edibles | Food products such as gummies and chocolates infused with psilocybin. The dosage is simplified as the amount per serving is indicated by the manufacturers. |
| Capsules | These are tasteless and can be seamlessly added to your wellness routine. They contain only small amounts for a subtle enhancement to your daily regimen. |
| Drinks | Similar to edibles, but in a liquid form. These are versatile and come in different flavors like chocolate, coffee, or tea. |
Determining Your Dose at Magic Mushroom Dispensaries
Although magic mushrooms are not typically used as a depression treatment, Canada has taken a progressive approach. They have approved the testing and medicinal use of psilocybin, a substance classified as Schedule I under the Controlled Drugs and Substances Act, for certain patients suffering from severe major depressive disorder. This decision could potentially provide relief to tens of thousands.
Individuals suffering from anxiety and depression often explore alternative treatment options through clinical trials.
Commonly Asked Questions
Is it feasible to buy psilocybin from a medicinal mushroom dispensary?
A medicinal mushroom dispensary usually offers products like Reishi, Turkey Tail, and Lion’s Mane. If you’re considering exploring the mushroom world, an online magic mushroom dispensary could be your ideal destination. Such dispensaries specialize in an array of mushroom products, including dried mushrooms and other psychedelic substances.
Is a 25 mg dosage effective for depression treatment?
Research on varying psilocybin dosages for depression treatment is in progress. Some studies have targeted lower dosages, while others have investigated higher psilocybin quantities. One possible approach could be to begin with a microdose and gradually increase the dosage.
Can one buy shrooms in Toronto?
Online mushroom retailers offer the convenience of shopping from anywhere in Canada. Regardless of your province or city, these online platforms ensure delivery to your doorstep.
Which is the most cost-effective product in an online mushroom shop?
Dried mushrooms are often the preferred choice for customers due to the wide selection of quantities available. The price can fluctuate based on whether you require a small amount such as 1 gram or plan to purchase in bulk. While edibles and other products are fairly priced, they may not be as economical as dried mushrooms.
Can a single shrooms dose help alleviate depression?
Some studies indicate that a one-time usage could potentially reduce symptoms of depression. However, it’s important to remember that most study participants also underwent talk therapy in addition to the treatment. The combination of psychedelic therapy and therapeutic sessions appears to yield the best results.
About the Author
The authors of this article are Charles L. Raison et al.; Jeremy D. Coplan, MD and Dorothy P. Reddy, MD; Albert Garcia-Romeu, Frederick S Barrett, Theresa M Carbonaro, Matthew W Johnson, and Roland R Griffiths; Vince Polito
Richard J. Stevenson, Rebecca Smausz, Joanna Neill, and John Gigg are also contributors.
Affiliated Institutions:
- Usona Institute in Fitchburg, Wisconsin
- SUNY Downstate Medical Center in Brooklyn, New York
- Neurogenesis Clinics in Brooklyn, New York
- Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA
- Department of Cognitive Science, Macquarie University, Sydney, Australia
- Department of Psychology, Macquarie University, Sydney, Australia
- The Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
- Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
- Medical Psychedelics Working Group, Drug Science, UK
